Bone marrow transplantation, stem cells from the infusion of bone marrow

Bone marrow transplantation, stem cells from the infusion of bone marrow to form new?


How stem cells into bone marrow, and survival in the bone marrow, bone marrow updated? The original bone marrow in patients with it? Does not work? Or be removed?

Questions added:

Seen some places that is blood type change after transplantation of bone marrow, is how the case?

After pretreatment, patient build school system was destroyed, if not entered into the seed (that is, stem cells of patients facing death.) Stem cells through intravenous, is the new seeds, it can re-create school systems in patients, of course, if there is residual and the patient's own very likely to relapse.

Pretreatment can kill all or part of the bone marrow stem cells.
After transplantation blood type will be determined mainly by the donor, but patients may still retain the original part of the hematopoietic function.


This will not change

【About bone marrow transplantation and (autologous peripheral blood) stem cell transplantation】
Bone marrow transplantation and (autologous peripheral blood) stem cell transplantation is to transplant hematopoietic stem cells, as hematopoietic stem cells were present in the bone marrow, early extraction of stem cells rely on bone marrow biopsy, using a needle bone marrow extraction and transplantation, which is your said bone marrow transplantation; this drawback is obvious, the first bone marrow donor to cause pain, imagine the needle then abruptly plunging more than it hurt your spine, and the recovery slow, risky; because there is a small amount of hematopoietic stem cells in autologous peripheral blood, so was born instead (autologous peripheral blood) hematopoietic stem cell transplantation, this method is by stem cell donors of blood leads to in vitro and in vitro through the special equipment cycle, ultimately, into the body, related equipment will be Separation of hematopoietic stem cells in the blood; the advantage is to avoid the bone marrow aspirate, no pain, and rapid recovery, the risk is very small;

Bone marrow transplantation (autologous peripheral) types of hematopoietic stem cell transplantation Introduction:
(1) autologous bone marrow transplantation (ABMT) or autologous peripheral blood stem cell transplantation (APBCT): ABMT and treatment of CML APBSCT main purpose is to extend to the late chronic phase or chronic phase patients back to prolong survival.
(2) with bone marrow transplantation: this BMT BMT is the treatment of CML patients and the first attempt.
(3) allogeneic bone marrow transplantation: allogeneic bone marrow transplantation (ALLo-BMT) is now able to complete almost the only means of cure CML, but also the best way to treat CML.
(4), accelerated phase and blast phase CML Once the treatment of accelerated phase of disease and more unstable conditions, about 2 / 3 of patients will be followed by rapid changes occur. This phase of CML has been late, treatment is difficult.

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【】 On cord blood transplantation
Maternal and fetal cord blood is the transport of nutrients between the channel, because the fetus comes from the fertilized egg, the cells are in a relatively early differentiation, a primitive, especially in cord blood, which is the originator of hematopoietic cells, height is not differentiation, with high totipotency, according to the need to differentiate into different hematopoietic cells (and bone marrow function much like the most.)

Why choose cord blood it?
First of all leukemia bone marrow transplant can not use their own stem cells, because the current technology can not guarantee that stem cells from the body without residual leukemia cells, it is necessary to use different genes. Different genes but also of finding matching bone marrow is how difficult, and the mother's second child because of family ties and patients, matching the likelihood of success is very great.
In addition, the closer genetic relationship, the smaller the possibility of rejection, but also more likely successful transplantation.


Finally, the success of transplant medicine refers to the position of patients do not relapse after a period of time (usually 1 year) can be called a success, and transplant patients without recurrence one year later on the very small chance of recurrence. So put this medical condition called graft success, which is cured.