Serum levels of apolipoprotein M and gestational diabetes in pregnant women

Serum levels of apolipoprotein M in normal pregnancy and gestational diabetes in pregnant women change

Recently, researchers MCH subsidiary Changzhou, Nanjing Medical University, published "serum apolipoprotein M levels in normal pregnancy and gestational diabetes in pregnant women change," which was published in the 2014 first nine "Journal of Endocrinology and Metabolism" .

Objective To investigate the maternal serum apolipoprotein M (ApoM) changes in the level of development of relations between the different pregnancy and cord blood and with gestational diabetes mellitus (GDM) occur. Methods June 2011 to April 2013 in Changzhou City of Women and Children hospital for regular prenatal care for pregnant women, 99 cases of normal pregnant women in the second trimester, third trimester of 122 cases, 100 cases of newborns, GDM pregnant women, 87 cases, serum lipid levels and other ApoM observe the relationship between levels of GDM and ApoM changes ApoM levels normal pregnant women and newborn cord blood at different stages. results (1) normal pregnant women in the second trimester serum ApoM level (0.036 ± 0.013) g / L, the third trimester ApoM level (0.023 ± 0.008) g / L, cord blood of newborns ApoM level (0.010 ± 0.004) g / L; (2) GDM ApoM maternal serum levels than the control group [(0.029 ± 0.010 对 0.036 ± 0.013) g / L, P <0 .05="" span=""> using multi-non-conditional logistic regression analysis, after controlling for confounding factors, the differences in serum levels of ApoM GDM and control groups remained significant (Z = -3.62, P <0 .05="" span=""> Conclusion fall pregnant women during pregnancy to increase the presence of serum levels after ApoM trends, neonatal cord blood levels were significantly lower than in ApoM pregnancy pregnant women; higher serum glucose levels ApoM GDM women decreased, suggesting ApoM may play a role in the pathophysiology of GDM.